ETRIS: Education & Training Resources in In-Vivo Sciences

Ethics and the 3Rs

Severity Assessment Framework

Severity Assessment Framework provides guidance on how to consider and report the severity of a procedure before, during and after the procedure The resource includes information on the general considerations when assessing severity, pre-study conditions, indicators of severity, how to ensure consistency in determining severity and tools for monitoring severity. It includes examples from many different research areas. A poster of the framework can be downloaded from

It was produced by an Expert Working Group established by the European Commission, the EU executive body. Copyright is retained by the European Commission.

This resource will be of use to all individuals involved in severity assessments, be they researchers, animal welfare staff or members of ethical review bodies. For colleagues within EU, it facilitates compliance with the requirements of Directive 201/63/EU.

Other resources in this category:

  • Animal Welfare Bodies and National Committees - view
  • Animal Welfare, Ethics and the 3Rs: Training materials and resources - view
  • Ethical Review - view
  • Guiding Principles on Good Practice for Animal Welfare and Ethical Review Bodies - view
  • Harm-Benefit Analysis - view
  • Humane Endpoints - view
  • IACUCorner - view
  • Lay Members Handbook - view
  • Norecopa - view
  • Project Evaluation and Retrospective Assessment - view
  • Severity Assessment Framework - view
  • The R of Replacement - view
  • Three Rs Microsite - view

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