ETRIS: Education & Training Resources in In-Vivo Sciences

Ethics and the 3Rs

Three Rs Microsite

Three Rs Microsite provides information, guidance and resources to facilitate the implementation of the replacement, refinement and reduction (3Rs) of animal use in research.

The resource comprises of information on the 3Rs, strategies for their implementation in animal care, husbandry and research, and resources for ethics committee (IUCAC/AWERB’s) members including additional resources for lay members. Application of the 3Rs is facilitated by including: an Animal Index ( which groups 3Rs resources by category and/or species of animal to assist in finding resources specific to certain types of animals; an animal use protocol worksheet (; a 3Rs Search Guide ( providing instructions on how to conduct a 3Rs information search; an Alternative Test Methods Table ( which provides information on non-animal alternative regulatory tests; links to 3Rs journals.

This resource was developed by the Canadian Council on Animal Care. Copyright of the materials is retained by this organisation.

The 3Rs microsite will be of benefit to animal care staff, researchers and members of ethical review committees in the application of good practice in the 3Rs to their work.

Other resources in this category:

  • Animal Welfare Bodies and National Committees - view
  • Animal Welfare, Ethics and the 3Rs: Training materials and resources - view
  • Ethical Review - view
  • Guiding Principles on Good Practice for Animal Welfare and Ethical Review Bodies - view
  • Harm-Benefit Analysis - view
  • Humane Endpoints - view
  • IACUCorner - view
  • Lay Members Handbook - view
  • Norecopa - view
  • Project Evaluation and Retrospective Assessment - view
  • Severity Assessment Framework - view
  • The R of Replacement - view
  • Three Rs Microsite - view

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