ETRIS: Education & Training Resources in In-Vivo Sciences

Ethics and the 3Rs

Harm-Benefit Analysis

*The Harm-Benefit Analysis Process * provides guidance on how to undertake a harm-benefit analysis for studies involving research animals.

The resource provides guidance on the process utilised by the UK Home Office for conducting harm-benefit analysis of project licence applications for studies using research animals regulated by the UK Animal (Scientific Procedures) Act 1986 (A(SP)A). It includes the legislative framework, the 3Rs, existing guidance, how Home Office Inspectors undertake such analyses and their assessment form. It should be read alongside Appendix I of the Guidance on the Operation of A(SP)A.

This publication was written by the UK Governments Animals in Science Regulation Unit. It is licensed for use under the terms of the Open Government Licence v3.0, with copyright being retained by the UK Government.

This guidance is of direct relevance to UK researchers applying for project licences under the Animal (Scientific Procedures) Act. It will be of benefit to members of ethical review/animal welfare bodies elsewhere in the world seeking guidance/good practice on undertaking harm-benefit analyses of studies involving research animals

Undergraduate and Taught Masters Research Animal Sciences curricula

This resource could be used in the delivery of the following Learning Outcome:

  • The ethical principles of the use of research animal, including Harm-benefit analysis

It could either be used to educate students as what regulators or research animal ethics committees considered when undertaking a harm-benefit analysis of a project application, or in an active learning session, where students work in groups to undertake their own harm-benefit analysis of an application

Other resources in this category:

  • Animal Welfare Bodies and National Committees - view
  • Animal Welfare, Ethics and the 3Rs: Training materials and resources - view
  • Ethical Review - view
  • Guiding Principles on Good Practice for Animal Welfare and Ethical Review Bodies - view
  • Harm-Benefit Analysis - view
  • Humane Endpoints - view
  • IACUCorner - view
  • Lay Members Handbook - view
  • Norecopa - view
  • Project Evaluation and Retrospective Assessment - view
  • Severity Assessment Framework - view
  • The R of Replacement - view
  • Three Rs Microsite - view

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